Frenkel J K, Pfefferkorn E R, Smith D D, Fishback J L
Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
Am J Vet Res. 1991 May;52(5):759-63.
Kittens are the principal disseminators of Toxoplasma gondii. They can shed greater than 10(8) oocysts in the feces after initial infection with bradyzoites in tissue cysts. Thereafter, most kittens develop protective immunity and do not shed oocysts again if they are reinfected. Bradyzoites of a T gondii mutant, designated T-263, were used to vaccinate kittens. Their use did not result in oocyst shedding, but successfully prevented 84% (31/37) of the kittens from shedding oocysts when challenge exposed with a normal isolate of T gondii. Vaccination of outdoor-roaming cats and kittens would be a useful public health measure to prevent transmission of toxoplasmosis near homes, on farms, and in zoos. It is anticipated that several years will be required for a lyophilized bradyzoite vaccine to be ready for licensing and possible commercial availability.
小猫是刚地弓形虫的主要传播者。它们在初次感染组织囊肿中的缓殖子后，粪便中可排出超过10⁸个卵囊。此后，大多数小猫会产生保护性免疫，如果再次感染，就不会再排出卵囊。一种名为T-263的刚地弓形虫突变体的缓殖子被用于给小猫接种疫苗。使用该缓殖子并未导致卵囊排出，但在用刚地弓形虫正常分离株进行攻击暴露时，成功预防了84%（31/37）的小猫排出卵囊。给户外流浪猫和小猫接种疫苗将是一项有用的公共卫生措施，可预防家庭附近、农场和动物园中弓形虫病的传播。预计冻干缓殖子疫苗需要数年时间才能准备好获得许可并可能投入商业使用。
