来自灰绿弯籽木和图氏番金莲木的腈苷和血清托贝宁

Nitrile glucosides and serotobenine from Campylospermum glaucum and Ouratea turnarea.

作者信息

Abouem à Zintchem Auguste, Bikobo Dominique Ngono, de Théodore Atchadé Alex, Mbing Joséphine Ngo, Gangoue-Pieboji Joseph, Tih Raphael Ghogomu, Blond Alain, Pegnyemb Dieudonné Emmanuel, Bodo Bernard

机构信息

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.

出版信息

Phytochemistry. 2008 Aug;69(11):2209-13. doi: 10.1016/j.phytochem.2008.04.013. Epub 2008 Jun 10.

DOI:10.1016/j.phytochem.2008.04.013

PMID:18550131

Abstract

Two nitrile glucosides (1S,3S,4S,5R)-4-benzoyloxy-2-cyanomethylene-3,5-dihydroxycyclohexyl-1-O-beta-glucopyranoside (campyloside A) and (1S,3S,4S,5R)-5-benzoyloxy-2-cyanomethylene-3-hydroxy-4-(2-pyrrolcarboxyloxy)cyclohexyl-1-O-beta-glucopyranoside (campyloside B) were isolated from the stem roots of Campylospermum glaucum, whereas serotobenine was isolated from Ouratea turnarea. The structure elucidations were based on spectroscopic evidence. The biological assays of compounds and crude extract of plant species showed good antimicrobial activity of crude extracts against Gram-positive cocci.

摘要

从铁青弯籽木的茎根中分离出两种腈苷，即(1S,3S,4S,5R)-4-苯甲酰氧基-2-氰基亚甲基-3,5-二羟基环己基-1-O-β-D-吡喃葡萄糖苷（弯籽木苷A）和(1S,3S,4S,5R)-5-苯甲酰氧基-2-氰基亚甲基-3-羟基-4-(2-吡咯羧氧基)环己基-1-O-β-D-吡喃葡萄糖苷（弯籽木苷B），而从特氏奥雷木中分离出了血清托贝宁。结构解析基于光谱学证据。对这些化合物和植物物种粗提物的生物测定表明，粗提物对革兰氏阳性球菌具有良好的抗菌活性。