Rubacka Joseph M, Schmeidler James, Nomura Yoko, Luthra Rohini, Rajendran Khushmand, Abramovitz Robert, Chemtob Claude M
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
J Nerv Ment Dis. 2008 Jun;196(6):504-7. doi: 10.1097/NMD.0b013e3181775f05.
Posttraumatic stress disorder (PTSD) is associated with greater risk of developing comorbid depression. However, little is known about the relationship between specific PTSD symptom clusters and comorbid depression. Approximately 4 years after the World Trade Center (WTC) attacks, we examined the association between PTSD symptom clusters and depression severity among 64 mothers directly exposed to the WTC attacks. Severity scores were computed for each PTSD symptom cluster by summing symptom frequency. Partial correlations with depression severity were calculated separately for PTSD symptom clusters, controlling for demographic variables, time elapsed since the attacks, WTC attack exposure, meeting PTSD criterion A, and the other cluster scores. Higher arousal symptom cluster scores were significantly correlated with persistent depression, but the re-experiencing and avoidance symptom clusters were not. Subsequent analyses isolating shared symptoms of PTSD and depression from those unique to PTSD suggest a complex interrelationship among symptoms of arousal, numbing, and depression.
创伤后应激障碍（PTSD）与并发抑郁症的风险增加有关。然而，关于特定PTSD症状群与并发抑郁症之间的关系，我们所知甚少。在世界贸易中心（WTC）袭击事件发生约4年后，我们研究了64名直接暴露于WTC袭击事件的母亲中PTSD症状群与抑郁严重程度之间的关联。通过对症状频率求和来计算每个PTSD症状群的严重程度得分。针对PTSD症状群分别计算与抑郁严重程度的偏相关性，同时控制人口统计学变量、袭击事件发生后的时间、WTC袭击暴露情况、符合PTSD标准A的情况以及其他症状群得分。较高的唤醒症状群得分与持续性抑郁显著相关，但再体验和回避症状群则不然。随后的分析将PTSD和抑郁症的共同症状与PTSD特有的症状区分开来，结果表明唤醒、麻木和抑郁症状之间存在复杂的相互关系。
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