Nelson Christian J, Diblasio Chris, Kendirci Muammer, Hellstrom Wayne, Guhring Patricia, Mulhall John P
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering-Cancer Center, New York, NY 10022, USA.
J Sex Med. 2008 Aug;5(8):1985-90. doi: 10.1111/j.1743-6109.2008.00895.x. Epub 2008 Jun 28.
For the practicing clinician, appreciating Peyronie's disease (PD) significant negative psychological impact is apparent. Despite this, there exists not a single study using validated instruments assessing this issue.
To document the effect of PD on the psychosocial status of men.
The Center for Epidemiological Studies Depression scale (CES-D) for evaluation of depression and the SF-36 for quality of life assessment.
Men (N = 92; 54 +/- 11 years of age) presenting for PD evaluation completed the CES-D, Short Form-36 (SF-36), and an inventory regarding PD. Partners were not assessed.
A vast majority of men (88%) had a partner with a mean partner age of 49 +/- 11 years. The median duration of PD at presentation was 12 (1-360) months. As a whole, 48% were classified as depressed on the CES-D (26% moderate, 21% severe). These subjects were then placed into groups according to the length of time since diagnosis of PD. Length-of-time groups were: 0-6 months, 6-12 months, 12-18 months, and >18 months. The percent of men scoring above the CES-D cutoff for depression remained consistently high with no significant difference across time since diagnosis groups. These results are supported by data from the Mental Health subscale (MHS) of the SF-36 (lower scores indicate lower mental heath). For the entire sample, the MHS standardized mean of 46.80 was significantly lower (P < 0.05) than the general male population standardized mean of 50. The MHS means stayed consistently low (no statistical difference) across time since diagnosis groups.
Using validated instruments, we have demonstrated that 48% of men with PD have clinically meaningful depression that would warrant medical evaluation. This high level of depression stayed consistent across time since diagnosis. These data suggest that most men do not psychologically adjust to their diagnosis of PD and all men with PD should be considered appropriate mental health screening.
对于临床执业医生而言，佩罗尼氏病（PD）显著的负面心理影响显而易见。尽管如此，尚无一项研究使用经过验证的工具来评估这一问题。
记录PD对男性心理社会状况的影响。
用于评估抑郁的流行病学研究中心抑郁量表（CES-D）和用于生活质量评估的SF-36。
前来接受PD评估的男性（N = 92；年龄54±11岁）完成了CES-D、简短健康调查问卷（SF-36）以及一份关于PD的问卷。未对伴侣进行评估。
绝大多数男性（88%）有伴侣，伴侣的平均年龄为49±11岁。就诊时PD的中位病程为12（1 - 360）个月。总体而言，48%的男性在CES-D上被归类为抑郁（26%为中度，21%为重度）。然后根据自PD诊断以来的时间长度将这些受试者分组。时间长度分组为：0 - 6个月、6 - 12个月、12 - 18个月和>18个月。CES-D抑郁临界值以上得分的男性百分比一直居高不下，自诊断以来各时间段之间无显著差异。这些结果得到了SF-36心理健康子量表（MHS）数据的支持（得分越低表明心理健康状况越差）。对于整个样本，MHS标准化均值为46.80，显著低于（P < 0.05）男性总体标准化均值50。自诊断以来各时间段的MHS均值一直较低（无统计学差异）。
使用经过验证的工具，我们证明了48%的PD男性患有具有临床意义的抑郁症，需要进行医学评估。自诊断以来，这种高度抑郁一直保持一致。这些数据表明，大多数男性在心理上并未适应其PD诊断，所有PD男性都应被视为适合进行心理健康筛查。
