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豚鼠中耳镫骨肌的运动神经元:传入和传出递质

Motoneurons of the stapedius muscle in the guinea pig middle ear: afferent and efferent transmitters.

作者信息

Reuss Stefan, Al-Butmeh Sandy, Riemann Randolf

机构信息

Department of Anatomy and Cell Biology, Johannes Gutenberg-University, Saarstr. 19-21, D-55099 Mainz, Germany.

出版信息

Brain Res. 2008 Jul 24;1221:59-66. doi: 10.1016/j.brainres.2008.05.008. Epub 2008 May 15.

Abstract

The objective of the present study was to identify efferent and afferent transmitters of motoneurons of the stapedius muscle of the middle ear in order to gain more insight into the neuronal regulation of the muscle. To identify motoneurons, we injected the fluorescent neuronal tracer Fluorogold (FG) into the muscle after preparation of the middle ear in adult guinea pigs. Upon terminal uptake and retrograde neuronal transport, we observed FG in neurons located medial and ventral to the nucleus of the facial nerve ipsilateral to the injection site. Immunohistochemical studies of these motoneurons showed that the majority contains calcitonin gene-related peptide. Our data further demonstrate close spatial relationships of motoneurons to structures immunoreactive to either serotonin, substance P or neuronal nitric oxide and reveal that these neurons are under neuropeptidergic and nitrergic influence.

摘要

本研究的目的是确定中耳镫骨肌运动神经元的传出和传入递质,以便更深入地了解该肌肉的神经调节。为了识别运动神经元,我们在成年豚鼠制备中耳后,将荧光神经元示踪剂荧光金(FG)注入肌肉。在终末摄取和逆行神经元运输后,我们在注射部位同侧面神经核内侧和腹侧的神经元中观察到FG。对这些运动神经元的免疫组织化学研究表明,大多数含有降钙素基因相关肽。我们的数据进一步证明了运动神经元与对5-羟色胺、P物质或神经元型一氧化氮免疫反应的结构之间存在密切的空间关系,并表明这些神经元受到神经肽能和一氧化氮能的影响。

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