Age, sex, and hormonal status can be additional variables in prenatal dexamethasone exposure.

This Letter to Editors refers to "Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age dependent manner" by M. Nagano et al. (2008) 60, 364-371. The letter points to unexpected decrease of glucocorticoid receptors, which is rather consistent with anxiolytic effects and suggests that age, sex, and hormonal status of subjects may represent additional confounding variables.