Opreh O P, Abioye-Kuteyi E A, Aboderin A O, Giebel H, Bello I S, Senbanjo I O
Seventh-day Adventist Hospital, PMB 5513, Ile-Ife, Osun State, Nigeria.
Trans R Soc Trop Med Hyg. 2008 Sep;102(9):868-74. doi: 10.1016/j.trstmh.2008.05.002. Epub 2008 Jun 13.
Over 90% of the burden of malaria occurs in sub-Saharan Africa. Children, especially under-fives, are the most vulnerable. In Nigeria, Africa's most populous nation, it accounts for 25 and 30% of infant and childhood deaths, respectively. One hundred and seventy-six children who fulfilled clinical and parasitological criteria for the diagnosis of malaria, 26.4% of all under-fives, who presented to the Seventh Day Adventist Hospital in Ile-Ife during the months of May to September 2005 were studied to identify the factors that were associated with severe malaria in the target population. The proportion of children with severe malaria in the study was 17%, while the case-fatality rate was 3.5%. Of the 17 variables examined, high malaria parasite density, non-use of mosquito-bite preventive measures and poverty remained independently and significantly associated with an increased risk for severe malaria. Progress in stemming the burden of malaria depends on accurate knowledge and understanding of the epidemiology and control of the disease in the affected populations.
超过90%的疟疾负担发生在撒哈拉以南非洲地区。儿童，尤其是五岁以下儿童，是最脆弱的群体。在非洲人口最多的国家尼日利亚，疟疾分别占婴儿和儿童死亡人数的25%和30%。对2005年5月至9月期间前往伊费第七日基督复临安息日会医院就诊、符合疟疾临床和寄生虫学诊断标准的176名儿童（占所有五岁以下儿童的26.4%）进行了研究，以确定目标人群中与重症疟疾相关的因素。研究中重症疟疾儿童的比例为17%，病死率为3.5%。在所检查的17个变量中，高疟原虫密度、未采取防蚊叮咬预防措施和贫困仍然与重症疟疾风险增加独立且显著相关。减轻疟疾负担的进展取决于对受影响人群中该疾病的流行病学和控制情况的准确了解。
