How does genotype define phenotype? Microphysiology of a tropomyosin mutation in situ shows the limitations of reductionism.
作者信息
Marston Steven
机构信息
Imperial College London, NHLI, London SW3 6LY, UK.
出版信息
J Physiol. 2008 Jun 15;586(12):2821. doi: 10.1113/jphysiol.2008.155606.
Abstract
摘要
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本文引用的文献
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Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation.
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Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
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