Dobosz M, Sledzinski Z, Juszkiewicz P, Babicki A, Stanek A, Wajda Z, Basinski A
Second Department of General Surgery, Medical Academy in Gdańsk, Poland.
Hepatogastroenterology. 1991 Apr;38(2):139-42.
Acute pancreatitis was induced in 13 anesthetized dogs by retrograde injection of bile mixed with trypsin into the pancreatic duct. Six animals were treated with intravenous infusion of new synthetic antiprotease. Nafamostat Mesilate, at a dose of 1 mg/kg/h. Four out of seven untreated animals died during the experiment. All the treated dogs survived. Hemodynamic data were regularly monitored during a ten-hour observation period. Cardiac output, mean arterial pressure and left ventricular stroke volume decreased rapidly in the untreated animals. An increase in systemic vascular resistance and pulmonary vascular resistance was observed in dogs without treatment. Nafamostat Mesilate given as therapy significantly improved the hemodynamic parameters, and prevented the animals from developing shock. The study demonstrates an advantageous influence of synthetic antiprotease Nafamostat Mesilate on the course of acute experimental pancreatitis.
通过向胰管逆行注射混合胰蛋白酶的胆汁，在13只麻醉犬中诱发急性胰腺炎。6只动物接受静脉输注新合成的抗蛋白酶甲磺酸萘莫司他，剂量为1毫克/千克/小时。7只未治疗的动物中有4只在实验期间死亡。所有接受治疗的犬均存活。在10小时的观察期内定期监测血流动力学数据。未治疗的动物心输出量、平均动脉压和左心室搏出量迅速下降。未治疗的犬全身血管阻力和肺血管阻力增加。作为治疗给予的甲磺酸萘莫司他显著改善了血流动力学参数，并防止动物发生休克。该研究证明了合成抗蛋白酶甲磺酸萘莫司他对急性实验性胰腺炎病程的有利影响。
