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Myelinated nerve endings in human skin.人类皮肤中的有髓神经末梢。
Muscle Nerve. 2007 Jun;35(6):767-75. doi: 10.1002/mus.20771.
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Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse.酪氨酸羟化酶在成年小鼠的一小群背根神经节小神经元中表达。
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Effect of sympathetic and parasympathetic mediators on the release of calcitonin gene-related peptide and prostaglandin E from rat dura mater, in vitro.交感神经和副交感神经介质对大鼠硬脑膜降钙素基因相关肽和前列腺素E释放的体外影响。
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Effect of sumatriptan in different models of pain in rats.舒马曲坦对大鼠不同疼痛模型的影响。
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Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists.外周与中枢三叉神经血管神经元之间通讯的中断介导了5HT 1B/1D受体激动剂的抗偏头痛作用。
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4274-9. doi: 10.1073/pnas.0306147101. Epub 2004 Mar 11.
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Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization.镇痛药曲坦类药物在颅内疼痛动物模型中的作用：与中枢敏化发展的赛跑。
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Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.在脊髓横断大鼠中介导心脏交感神经抑制的5-羟色胺1型受体的进一步特性研究：与5-羟色胺1B和5-羟色胺1D亚型的药理学相关性
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Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans.三叉神经节和背根神经节中的肽能伤害感受器均表达5-羟色胺1D受体：对曲坦类药物选择性抗偏头痛作用的启示。
J Neurosci. 2003 Nov 26;23(34):10988-97. doi: 10.1523/JNEUROSCI.23-34-10988.2003.
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Therapeutic implications of central and peripheral neurologic mechanisms in migraine.偏头痛中中枢和外周神经机制的治疗意义
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10
The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.抗偏头痛的5-羟色胺1B/1D受体激动剂舒马曲坦、佐米曲坦和双氢麦角胺，可减轻三叉神经病理性疼痛大鼠模型中与疼痛相关的行为。
Br J Pharmacol. 2002 Dec;137(8):1287-97. doi: 10.1038/sj.bjp.0704979.

5-羟色胺1D型受体（5HTR）在支配颅面部组织的神经纤维中呈差异性分布。

Serotonin type 1D receptors (5HTR) are differentially distributed in nerve fibres innervating craniofacial tissues.

作者信息

Harriott A M, Gold M S

机构信息

Department of Biomedical Sciences and Medical Sciences Training Program, University of Maryland, Baltimore, MD, USA.

出版信息

Cephalalgia. 2008 Sep;28(9):933-44. doi: 10.1111/j.1468-2982.2008.01635.x. Epub 2008 Jun 28.

DOI:10.1111/j.1468-2982.2008.01635.x
PMID:18557979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2682350/
Abstract

We tested the hypothesis that the 5HT(1D)R, the primary antinociceptive target of triptans, is differentially distributed in tissues responsible for migraine pain. The density of 5HT(1D)R was quantified in tissues obtained from adult female rats with Western blot analysis. Receptor location was assessed with immunohistochemistry. The density of 5HT(1D)R was significantly greater in tissues known to produce migraine-like pain (i.e. circle of Willis and dura) than in structures in which triptans have no antinociceptive efficacy (i.e. temporalis muscle). 5HT(1D)R-like immunoreactivity was restricted to neuronal fibres, where it colocalized with calcitonin gene-related peptide and tyrosine hydroxylase immunoreactive fibres. These results are consistent with our hypothesis that the limited therapeutic profile of triptans could reflect its differential peripheral distribution and that the antinociceptive efficacy reflects inhibition of neuropeptide release from sensory afferents. An additional site of action at sympathetic efferents is also suggested.

摘要

我们验证了一个假说，即曲坦类药物的主要抗伤害感受靶点5HT(1D)R在引发偏头痛疼痛的组织中分布存在差异。通过蛋白质印迹分析对成年雌性大鼠组织中的5HT(1D)R密度进行定量。用免疫组织化学法评估受体定位。已知产生类偏头痛疼痛的组织（即 Willis 环和硬脑膜）中5HT(1D)R的密度显著高于曲坦类药物无抗伤害感受作用的结构（即颞肌）。5HT(1D)R样免疫反应仅限于神经纤维，在那里它与降钙素基因相关肽和酪氨酸羟化酶免疫反应纤维共定位。这些结果与我们的假说一致，即曲坦类药物有限的治疗谱可能反映其外周分布差异，且抗伤害感受作用反映了对感觉传入神经肽释放的抑制。还提示了在交感传出神经处的另一个作用位点。