Sanz-Muñoz C, Martínez-Morán C, Miranda-Romero A
Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Spain.
Actas Dermosifiliogr. 2008 Jul-Aug;99(6):477-80.
We describe the case of a 30-year-old woman who, 5 days after giving birth to her first child by cesarean section, presented with dehiscence of one end of the surgical wound and a lesion on her leg that developed into a well-defined ulcer; both lesions were very painful. The patient was initially diagnosed with a skin infection and later with superficial pyoderma gangrenosum. The lesions were treated with topical corticosteroids and a good response was observed. No evidence was found of underlying disease. Isolated cases of pyoderma gangrenosum associated with pregnancy or cesarean delivery have been reported in the literature. The etiology of pyoderma gangrenosum is currently unknown, but some theories suggest an immunologic mechanism. Gestation is known to generate a state of immune tolerance that could play a role in the development of the disease and future studies may help to clarify the significance of this association.
我们描述了一名30岁女性的病例,她在剖宫产下第一个孩子5天后,出现手术伤口一端裂开,腿部出现一个病灶,发展成边界清晰的溃疡;两处病灶均疼痛剧烈。患者最初被诊断为皮肤感染,后来被诊断为浅表性坏疽性脓皮病。病灶接受了局部皮质类固醇治疗,观察到良好疗效。未发现潜在疾病的证据。文献中已报道了与妊娠或剖宫产相关的孤立性坏疽性脓皮病病例。坏疽性脓皮病的病因目前尚不清楚,但一些理论认为存在免疫机制。已知妊娠会产生免疫耐受状态,这可能在该疾病的发展中起作用,未来的研究可能有助于阐明这种关联的意义。