Mell Joshua Chang, Komachi Kelly, Hughes Owen, Burgess Sean
Genetics Graduate Group, Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA.
Genetics. 2008 Jun;179(2):1125-7. doi: 10.1534/genetics.108.088567.
We report a novel instance of negative interference during Saccharomyces cerevisiae meiosis, where Cre-mediated recombination between pairs of allelic loxP sites is more frequent than expected. We suggest that endogenous crossover recombination mediates cooperative pairing interactions between all four chromatids of a meiotic bivalent.
我们报道了酿酒酵母减数分裂过程中负干扰的一个新实例,其中等位基因loxP位点对之间的Cre介导的重组比预期更频繁。我们认为内源性交叉重组介导了减数分裂二价体所有四条染色单体之间的协同配对相互作用。