抗抑郁治疗可使重度抑郁症患者在情绪干扰处理过程中背外侧前额叶皮质的活动低下恢复正常。
Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression.
作者信息
Fales Christina L, Barch Deanna M, Rundle Melissa M, Mintun Mark A, Mathews Jose, Snyder Abraham Z, Sheline Yvette I
机构信息
Department of Psychology, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
出版信息
J Affect Disord. 2009 Jan;112(1-3):206-11. doi: 10.1016/j.jad.2008.04.027. Epub 2008 Jun 17.
BACKGROUND
Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive amygdala activity and under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry.
METHODS
Functional magnetic resonance imaging was conducted on depressed patients (n=23) (both before and after antidepressant treatment) compared with matched controls (n=18) while they performed a cognitive task involving attended and unattended fear-related stimuli.
RESULTS
After eight weeks of SSRI antidepressant treatment, patients with depression showed significantly increased DLPFC activity to unattended fear-related stimuli and no longer differed from controls in either DLPFC or amygdala activity.
CONCLUSIONS
These results suggest that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference.
LIMITATIONS
The sample was fairly homogeneous and this may limit generalizability.
背景
重度抑郁症（MDD）的特征是情绪处理改变和认知控制缺陷。在认知干扰任务中，MDD患者表现出杏仁核活动过度以及背外侧前额叶皮质（DLPFC）活动不足。本研究的目的是检验抗抑郁治疗对认知控制和情绪处理神经回路中异常神经活动的影响。
方法
对23名抑郁症患者（抗抑郁治疗前后）与18名匹配的对照组进行功能磁共振成像，同时他们执行一项涉及关注和未关注的恐惧相关刺激的认知任务。
结果
经过八周的SSRI抗抑郁治疗后，抑郁症患者对未关注的恐惧相关刺激表现出DLPFC活动显著增加，并且在DLPFC或杏仁核活动方面与对照组不再有差异。
结论
这些结果表明，抗抑郁治疗可增加在包括情绪干扰的认知任务期间DLPFC的活动不足。
局限性
样本相当同质化，这可能会限制普遍性。
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