Kehrle Helga M, Granjeiro Ronaldo C, Sampaio André L L, Bezerra Roberta, Almeida Vanessa F, Oliveira Carlos A
Department of Otolaryngology, Hospital de Base de Brasília, SQSW 306, Bloco A, Ap 208, Bairro Sudoeste, Brasília DF 70673431, Brazil.
Arch Otolaryngol Head Neck Surg. 2008 Jun;134(6):647-51. doi: 10.1001/archotol.134.6.647.
To evaluate electrophysiologically the auditory nerve and the auditory brainstem function of patients with tinnitus and normal-hearing thresholds using the auditory brainstem response (ABR).
Case-control study.
Ambulatory section of the Department of Otolaryngology, Hospital de Base de Brasília.
Thirty-seven individuals with tinnitus and 38 without tinnitus, with ages ranging from 20 to 45 years and pure-tone thresholds of 25 dB or better at frequencies between 500 and 8000 Hz.
We compared the latencies of waves I, III, and V; the interpeak intervals I-III, III-V, and I-V; the interaural latency difference (wave V); and the V/I amplitude ratio between the 2 groups.
Among the 37 patients in the study group, abnormal results were found in 16 (43%) in at least 1 of the 8 parameters evaluated. When we analyzed the latencies, although the values were on average in the normal range used in the present study, the tinnitus group presented a significant prolongation of the latencies of waves I, III, and V when compared with the control group. Furthermore, we found the interpeak I-III, III-V, and I-V values to be within the normal limits, but the interpeak III-V value was significantly (P = .003) enlarged in the study group compared with the control group. The V/I amplitude ratio found in the tinnitus group was within normal limits; however, a significant (P = .004) difference was found when the 2 groups were compared. The averages of the interaural latency difference (wave V) did not show significant differences in relation to the control group.
We conclude that, although the averages obtained in several analyzed parameters were within normal limits, the ABR results from the patients with and without tinnitus and normal hearing are different, suggesting that ABR might contribute to the workup of these patients. Our data show that there are changes in the central pathways in the study group. The meaning of these changes must be further investigated.
使用听性脑干反应（ABR）对耳鸣且听力阈值正常的患者的听神经和听性脑干功能进行电生理评估。
病例对照研究。
巴西利亚基地医院耳鼻喉科门诊。
37名耳鸣患者和38名无耳鸣患者，年龄在20至45岁之间，500至8000赫兹频率的纯音阈值为25分贝或更好。
我们比较了两组的波I、III和V的潜伏期；峰间期I-III、III-V和I-V；双耳潜伏期差异（波V）；以及V/I振幅比。
在研究组的37名患者中，16名（43%）在评估的8项参数中至少有1项结果异常。在分析潜伏期时，虽然本研究中使用的平均值在正常范围内，但耳鸣组与对照组相比，波I、III和V的潜伏期明显延长。此外，我们发现峰间期I-III、III-V和I-V值在正常范围内，但研究组的峰间期III-V值与对照组相比显著增大（P = 0.003）。耳鸣组的V/I振幅比在正常范围内；然而，两组比较时发现有显著差异（P = 0.004）。双耳潜伏期差异（波V）的平均值与对照组相比未显示出显著差异。
我们得出结论，尽管在几个分析参数中获得的平均值在正常范围内，但耳鸣患者和无耳鸣且听力正常患者的ABR结果不同，这表明ABR可能有助于对这些患者的检查。我们的数据表明研究组的中枢通路存在变化。这些变化的意义必须进一步研究。
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