间歇性普林格尔手法与结直肠癌肝转移切除术后的不良长期预后无关。

Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases.

作者信息

Wong K H V, Hamady Z Z R, Malik H Z, Prasad R, Lodge J P A, Toogood G J

机构信息

Hepatopancreatobiliary and Transplant Unit, St James's University Hospital, Leeds LS9 7TF, UK.

出版信息

Br J Surg. 2008 Aug;95(8):985-9. doi: 10.1002/bjs.6129.

DOI:10.1002/bjs.6129

PMID:18563791

Abstract

BACKGROUND

Intermittent clamping of the porta hepatis, or the intermittent Pringle manoeuvre (IPM), is often used to control inflow during parenchymal liver transection. The aim of this study was to determine whether IPM is associated with an adverse long-term outcome after liver resection for colorectal liver metastasis (CRLM).

METHODS

All patients undergoing resection for CRLM in 1993-2006, for whom data on IPM were recorded, were included in the study. A total of 563 patients was available for analysis.

RESULTS

IPM was performed in 289 (51.3 per cent) of the patients. The duration of IPM ranged from 2 to 104 (median 22) min. There were no differences in clinicopathological features or postoperative morbidity between patients who had an IPM and those who did not. The median survival of patients undergoing IPM was 55.7 months compared with 48.9 months in those not having an IPM (P = 0.406). There was no difference in median disease-free survival between the two groups (22.1 versus 19.9 months respectively; P = 0.199).

CONCLUSION

IPM is not associated with an adverse long-term prognosis in patients undergoing liver resection for CRLM.

摘要

背景

肝门间歇性阻断，即间歇性Pringle手法（IPM），常用于肝实质离断期间控制血流。本研究旨在确定IPM是否与结直肠癌肝转移（CRLM）肝切除术后的不良长期预后相关。

方法

纳入1993年至2006年期间所有接受CRLM切除术且记录了IPM数据的患者。共有563例患者可供分析。

结果

289例（51.3%）患者接受了IPM。IPM持续时间为2至104分钟（中位数22分钟）。接受IPM的患者与未接受IPM的患者在临床病理特征或术后发病率方面无差异。接受IPM的患者中位生存期为55.7个月，未接受IPM的患者为48.9个月（P = 0.406）。两组间无病生存期中位数无差异（分别为22.1个月和19.9个月；P = 0.199）。