Nitoda Teruhiko, Isobe Takahiko, Kubo Isao
Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112, USA.
Phytother Res. 2008 Jul;22(7):867-72. doi: 10.1002/ptr.2373.
Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC(50) of 30 microm (9.5 microg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
从日本香茶菜（唇形科）地上部分分离得到的踏板花素，对小鼠B16-F10黑色素瘤细胞系具有细胞毒性，半数抑制浓度（IC50）为30微摩尔（9.5微克/毫升）。当用这种黄酮培养细胞时，黑色素生成并未受到抑制，反而有所增强。从同一来源分离得到的槲皮素表现出类似的活性，但芦丁则没有活性。
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