Karnoub Antoine E, Weinberg Robert A
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31. doi: 10.1038/nrm2438.
Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to numerous insights that have revealed the involvement of Ras not only in tumorigenesis but also in many developmental disorders. Despite great strides in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.
在过去30年里,对Ras蛋白及其在细胞生理学中的功能进行了广泛研究,从而获得了许多见解,这些见解表明Ras不仅参与肿瘤发生,还与许多发育障碍有关。尽管我们对Ras蛋白的分子和细胞作用机制有了很大进展,但其下游效应器的不断增加以及它们所调节的信号级联的复杂性表明,仍有许多有待了解的地方。