由2-氨基苄基鏻盐一锅法合成2-取代吲哚。阿氏蓝菌素A的形式全合成。
One-pot synthesis of 2-substituted indoles from 2-aminobenzyl phosphonium salts. A formal total synthesis of arcyriacyanin A.
作者信息
Kraus George A, Guo Haitao
机构信息
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
出版信息
Org Lett. 2008 Jul 17;10(14):3061-3. doi: 10.1021/ol801034x. Epub 2008 Jun 24.
PMID:18572918
Abstract
The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or alpha,beta-unsaturated aldehydes under microwave-assisted conditions constitutes a new synthesis of 2-substituted indoles in high yields (81-97%) in a one-pot reaction. The adduct from indole-4-carboxaldehyde was an advanced intermediate in the synthesis of arcyriacyanin A.
摘要
（2-氨基苄基）三苯基溴化鏻与芳香醛或α，β-不饱和醛在微波辅助条件下反应，能在一锅反应中高产率（81-97%）地合成2-取代吲哚，这是一种新的合成方法。吲哚-4-甲醛生成的加合物是合成刺孢蓝菌素A的一种高级中间体。
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