七无膜结合配体的“新娘”与七无酪氨酸激酶受体的相互作用。

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.

作者信息

Krämer H, Cagan R L, Zipursky S L

机构信息

Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024-1737.

出版信息

Nature. 1991 Jul 18;352(6332):207-12. doi: 10.1038/352207a0.

DOI:10.1038/352207a0

PMID:1857416

Abstract

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

摘要

在果蝇视网膜发育过程中，R8光感受器神经元诱导相邻细胞获得R7细胞命运。遗传数据表明，这种诱导是由七无之新娘基因和七无基因编码的两种跨膜蛋白介导的。表达这两种蛋白的细胞系的异型聚集证明了这两种蛋白之间存在直接相互作用。在发育中的眼睛中，R7前体细胞对七无之新娘的七无依赖内化作用为这两种蛋白在体内的直接相互作用提供了证据。