人类端粒酶在端粒之外的作用。

Actions of human telomerase beyond telomeres.

作者信息

Cong Yusheng, Shay Jerry W

机构信息

Key laboratory for Cell Proliferation and Regulation Biology of the Ministry of Education, Institute of Cell Biology, Beijing Normal University, 19 Xin Jie Kou Wai Avenue, Beijing 100875, China.

出版信息

Cell Res. 2008 Jul;18(7):725-32. doi: 10.1038/cr.2008.74.

DOI:10.1038/cr.2008.74

PMID:18574498

Abstract

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.

摘要

端粒酶在维持端粒稳态和完整性方面发挥着重要作用，可绕过细胞衰老并促进癌症进展。然而，最近的研究使一些研究人员提出，端粒酶在几种重要的细胞信号通路中具有新的生化特性，而其在端粒维持中的既定功能并未明显参与其中。这些观察结果可能会进一步加深我们对端粒酶在衰老和癌症中分子作用的理解。本综述将提供关于端粒酶在细胞凋亡、DNA修复、干细胞功能以及基因表达调控等方面的“课外活动”的最新情况。