Escobar-Morreale Héctor F, Botella-Carretero José I, Martínez-García Ma Angeles, Luque-Ramírez Manuel, Alvarez-Blasco Francisco, San Millán José L
Department of Endocrinology, Hospital Ramón y Cajal & Universidad de Alcalá, Madrid, Spain.
Eur J Endocrinol. 2008 Sep;159(3):225-32. doi: 10.1530/EJE-08-0107. Epub 2008 Jun 25.
Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, has a variety of functions including anti-inflammatory effects and a possible cardiovascular protective role. Both low-grade chronic inflammation and cardiovascular risk are increased in women with the polycystic ovary syndrome (PCOS). We aimed to study serum OPG concentrations in PCOS patients.
Case-control study including 40 PCOS patients matched with 40 non-hyperandrogenic women for age and body mass index.
Basal serum sampling and standard oral glucose tolerance test, and measurement of serum OPG concentrations by commercial ELISA.
Serum OPG concentrations were lower in women with PCOS compared with those of controls (304+/-120 vs 363+/-105 pg/ml respectively; F=7.641, P=0.007) independently of obesity. No differences were observed in serum receptor activator of nuclear factor-kappaB ligand (RANKL) levels and in the RANKL/OPG molar ratio. A multivariate linear regression model (R(2)=0.208, F=6.579, P=0.001) showed that PCOS (beta=-0.281, P=0.008), obesity (beta=-0.245, P=0.022) and age (beta=0.296, P=0.006) were predictive of serum OPG concentrations.
Serum OPG concentrations are reduced in PCOS patients independently of obesity. Considering the anti-inflammatory effects of OPG, its reduced serum concentrations might contribute to the proinflammatory state and cardiovascular risk of PCOS patients.
骨保护素（OPG）是破骨细胞性骨吸收的抑制剂，具有多种功能，包括抗炎作用以及可能的心血管保护作用。多囊卵巢综合征（PCOS）女性的低度慢性炎症和心血管风险均增加。我们旨在研究PCOS患者的血清OPG浓度。
病例对照研究，纳入40例PCOS患者，并与40名年龄和体重指数相匹配的非高雄激素血症女性进行对照。
进行基础血清采样和标准口服葡萄糖耐量试验，并采用商业酶联免疫吸附测定法（ELISA）测量血清OPG浓度。
PCOS女性的血清OPG浓度低于对照组（分别为304±120 vs 363±105 pg/ml；F=7.641，P=0.007），且不受肥胖影响。血清核因子κB受体活化因子配体（RANKL）水平和RANKL/OPG摩尔比未见差异。多变量线性回归模型（R²=0.208，F=6.579，P=0.001）显示，PCOS（β=-0.281，P=0.008）、肥胖（β=-0.245，P=0.022）和年龄（β=0.296，P=0.006）可预测血清OPG浓度。
PCOS患者的血清OPG浓度降低，且不受肥胖影响。鉴于OPG的抗炎作用，其血清浓度降低可能导致PCOS患者的促炎状态和心血管风险。
