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食管癌手术后与健康相关的长期生活质量。

Long-term health-related quality of life following surgery for oesophageal cancer.

作者信息

Djärv T, Lagergren J, Blazeby J M, Lagergren P

机构信息

Unit of Oesophageal and Gastric Research, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

出版信息

Br J Surg. 2008 Sep;95(9):1121-6. doi: 10.1002/bjs.6293.

Abstract

BACKGROUND

The aim of the study was to assess health-related quality of life (HRQL) in patients with surgically cured oesophageal cancer.

METHODS

A Swedish nationwide cohort of patients undergoing oesophagectomy for cancer between April 2001 and January 2004 was studied prospectively, and compared with a Swedish age- and sex-adjusted reference population. Validated European Organisation for Research and Treatment of Cancer quality of life questionnaires were used to assess HRQL at 6 months and 3 years after surgery. A mean score difference of 10 or more between groups was considered clinically relevant and tested further for statistical significance.

RESULTS

Of 358 patients, 117 (32.7 per cent) survived for at least 3 years. Of these, 87 patients (74.4 per cent) responded to the questionnaires. Six months after surgery, most aspects of HRQL were substantially worse than in the reference population with no improvement at 3 years. Patients alive at 3 years reported significantly poorer role and social function, and significantly more problems with fatigue, diarrhoea, appetite loss, nausea and vomiting, than in the reference population.

CONCLUSION

HRQL in long-term survivors after oesophagectomy does not improve between 6 months and 3 years after surgery, and is worse than that in a comparable reference population.

摘要

背景

本研究旨在评估手术治愈的食管癌患者的健康相关生活质量(HRQL)。

方法

对2001年4月至2004年1月间在瑞典接受食管癌切除术的全国性队列患者进行前瞻性研究,并与瑞典年龄和性别调整后的参考人群进行比较。使用经过验证的欧洲癌症研究与治疗组织生活质量问卷在术后6个月和3年评估HRQL。两组之间平均得分差异10分或更多被认为具有临床相关性,并进一步进行统计学显著性检验。

结果

358例患者中,117例(32.7%)存活至少3年。其中,87例患者(74.4%)对问卷做出了回应。术后6个月,HRQL的大多数方面比参考人群差得多,3年时无改善。存活3年的患者报告其角色和社会功能明显较差,疲劳、腹泻、食欲减退、恶心和呕吐问题也明显多于参考人群。

结论

食管癌切除术后长期存活者的HRQL在术后6个月至3年之间没有改善,且比可比的参考人群差。

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