Gennari S M, Bressan M C, Rogero J R, MacLean J M, Duncan J L
Dept. de Paragitologia, Universidade de São Paulo, Brazil.
Vet Parasitol. 1991 Mar;38(2-3):163-72. doi: 10.1016/0304-4017(91)90126-g.
This study was conducted to investigate the pathophysiology of Haemonchus placei infection in Friesian calves. Seven calves were divided into two groups, three uninfected calves (control group) and four infected animals. The latter group were infected orally with 500 H. placei larvae kg-1 body weight. Five weeks after infection they were all housed in metabolic crates and injected with 125I-bovine albumin. 51Cr-red cells and 59Fe-transferrin, to study albumin metabolism, erythrokinetics and ferrokinetics. The results showed that there was a significant reduction in the mean haematocrit values and reduced weight gains in the infected calves compared with the controls. There was also a change in the distribution of albumin from the extravascular to the intravascular pool and a significant increase in the plasma and blood volumes of infected calves although the blood and albumin loss via the gastrointestinal tract recorded in this study was similar in both groups.
本研究旨在调查弗里斯兰犊牛感染捻转血矛线虫的病理生理学。将7头犊牛分为两组，3头未感染的犊牛（对照组）和4头感染动物。后一组经口感染500条捻转血矛线虫幼虫/千克体重。感染5周后，将它们全部安置在代谢笼中，并注射125I-牛白蛋白、51Cr-红细胞和59Fe-转铁蛋白，以研究白蛋白代谢、红细胞动力学和铁动力学。结果表明，与对照组相比，感染犊牛的平均血细胞比容值显著降低，体重增加减少。感染犊牛的白蛋白从血管外池向血管内池的分布也发生了变化，血浆和血容量显著增加，尽管本研究记录的两组经胃肠道的血液和白蛋白损失相似。
