Chattaway T, Goma G, Renaud P Y
INSA, Département de Génie Biochimique et Alimentaire, ERA CNRS No 879, Avenue de Rangueil, 31077 Toulouse Cedex, France.
Biotechnol Bioeng. 1988 Jul 20;32(3):271-6. doi: 10.1002/bit.260320303.
A kinetic model of ethanol fermentation conducted under a variety of conditions in a continuous four-stage reactor is proposed. The expressions for specific growth and product formation rates are: micro = micro0 exp(-k1P)(1- X/X1) nu P = nu0 exp(-k2P (1 - X/X2). Parameters were identified by nonlinear programming and shown to fit data correctly for steady states of seven different experiments. The product inhibition constants were of 27 and 84 g/L, respectively. Secondary inhibitions were represented by the linear biomass term. The proposed model gave a better description of phenomena than one which only took ethanol inhibition into account. The same model also fitted batch fermentation data, with only some parameters altering significantly. The use of this model for on-line purposes is discussed.
提出了在连续四级反应器中多种条件下进行乙醇发酵的动力学模型。比生长速率和产物形成速率的表达式为：μ = μ₀ exp(-k₁P)(1 - X/X₁)，νP = ν₀ exp(-k₂P (1 - X/X₂)。通过非线性规划确定参数，并表明其能正确拟合七个不同实验稳态的数据。产物抑制常数分别为27 g/L和84 g/L。二次抑制由线性生物量项表示。所提出的模型比仅考虑乙醇抑制的模型能更好地描述现象。同一模型也能拟合间歇发酵数据，只是一些参数有显著变化。讨论了该模型用于在线目的的情况。
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