静脉注射可卡因或苯丙胺的给药速度不会影响大鼠的吸毒和觅药行为。
The rate of intravenous cocaine or amphetamine delivery does not influence drug-taking and drug-seeking behavior in rats.
作者信息
Crombag Hans S, Ferrario Carrie R, Robinson Terry E
机构信息
Department of Psychology and Neuroscience Program, The University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1109, USA.
出版信息
Pharmacol Biochem Behav. 2008 Oct;90(4):797-804. doi: 10.1016/j.pbb.2008.06.003.
We studied the influence of rate of intravenous infusion of cocaine or amphetamine on drug-taking and seeking behavior. First, drug-naive rats were tested for acquisition of self-administration of increasing doses of amphetamine or cocaine infused over 5 or 100 s. Second, self-administration of cocaine or amphetamine infused over 5-100 s was assessed on fixed or progressive-ratio (PR) reinforcement schedules. Finally, the ability of a single 5 or 100 s amphetamine or cocaine infusion to reinstate extinguished drug seeking was assessed. Although slower infusion rates produced a small effect on drug taking under continuous-reinforcement conditions, infusion rate did not alter drug taking on intermittent or PR reinforcement schedules, or the ability of cocaine or amphetamine to reinstate drug seeking. Taken together, our results suggest that variation in drug delivery rate over a range that we previously found alters the induction of behavioral sensitization, gene-expression and striatal dopamine activity, does not markedly alter drug-taking or seeking behavior.
我们研究了静脉注射可卡因或苯丙胺的速率对药物摄取和觅药行为的影响。首先，对未接触过药物的大鼠进行测试，观察它们对在5秒或100秒内输注递增剂量苯丙胺或可卡因的自我给药习得情况。其次，在固定或累进比率（PR）强化程序下评估在5 - 100秒内输注可卡因或苯丙胺的自我给药情况。最后，评估单次5秒或100秒的苯丙胺或可卡因输注恢复已消退觅药行为的能力。尽管在持续强化条件下，较慢的输注速率对药物摄取产生了较小影响，但输注速率并未改变间歇或PR强化程序下的药物摄取，也未改变可卡因或苯丙胺恢复觅药行为的能力。综合来看，我们的结果表明，在我们之前发现会改变行为敏化诱导、基因表达和纹状体多巴胺活性的范围内，药物递送速率的变化并未显著改变药物摄取或觅药行为。
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