Tsai H-T, Tsai Y-M, Yang S-F, Lee C-H, Lin L-Y, Lee S, Wu M-T
School of Nursing College, Chung Shan Medical University, Taichung, Taiwan.
Pathol Biol (Paris). 2009 Sep;57(6):477-82. doi: 10.1016/j.patbio.2008.05.006. Epub 2008 Jun 30.
Papanicolaou (Pap) smear test is implemented to detect cervical intraepithelial neoplasia (CIN) in Taiwan. However, the utility of that has limitations. High-risk human papillomavirus (HR-HPV) is an important risk factor in development of cervical cancer. In this study, we estimate the utility of HR-HPV testing in the screening of CIN.
Firstly, 726 subjects were recruited and willing to prove cervical exfoliated epithelial cells for Pap smear screening and HR-HPV DNA testing. Subsequently, 205 of the eligible subjects with greater than or equal to CIN1 of Pap smear results were asked to perform histologic diagnosis that served as a gold standard for the estimation of the effects of both Pap smear and HR-HPV testing.
The histology is significantly associated with HR-HPV infection, as well as significantly highly correlated with the individuals who have both Pap smear greater than or equal to CIN1 and positive HR-HPV infection but not significantly correlated with the individuals who only have Pap smear greater than or equal to CIN1 but without HR-HPV infection.
Combinative surveillance of HR-HPV infection and Pap smear is a useful tool to detect and monitor precancerous lesions in the screening program. HR-HPV testing is a notable accessory screening program for detection of CIN in Taiwanese women.
在台湾，巴氏涂片检查用于检测宫颈上皮内瘤变（CIN）。然而，其效用存在局限性。高危型人乳头瘤病毒（HR-HPV）是宫颈癌发生的一个重要危险因素。在本研究中，我们评估HR-HPV检测在CIN筛查中的效用。
首先，招募726名受试者，她们愿意提供宫颈脱落上皮细胞用于巴氏涂片筛查和HR-HPV DNA检测。随后，对巴氏涂片结果大于或等于CIN1的205名合格受试者进行组织学诊断，作为评估巴氏涂片和HR-HPV检测效果的金标准。
组织学与HR-HPV感染显著相关，并且与巴氏涂片大于或等于CIN1且HR-HPV感染呈阳性的个体高度相关，但与仅巴氏涂片大于或等于CIN1但无HR-HPV感染的个体无显著相关性。
HR-HPV感染与巴氏涂片联合监测是筛查计划中检测和监测癌前病变的有用工具。HR-HPV检测是台湾女性检测CIN的一项重要辅助筛查计划。
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