Tanriverdi Taner, Poulin Nicole, Olivier Andre
Montreal Neurological Institute, Neurosurgery, Montreal/Quebec, Canada.
Turk Neurosurg. 2008 Apr;18(2):114-24.
The purpose of this prospective clinical study was to examine the short- and long-term psychosocial outcomes of a consecutive series of patients who underwent extratemporal lobe resection due to medically-refractory epilepsy.
The sample consisted of 23 consecutive patients and all patients completed a questionnaire assessing especially psychosocial outcome 6 months and 2 years after surgery. Results obtained at short- and long-term follow-ups were compared to baseline. Furthermore, the impact of seizure freedom on the psychosocial outcome was sought.
The results suggested that, psychosocial outcome was improved after surgery compared to preoperative status regardless of seizure status. At long-term follow-up, significant improvements were found in social and psychological variables (p < 0.05). Levels of side effects from medication were high at long-term compared to baseline (p = 0.003). Seizure free patients showed better psychosocial outcome than those who had seizure during the postoperative period, however; only the "impact of epilepsy" scale showed significant improvement at 6 months after surgery (p = 0.02).
These results provide evidence that surgery caused appreciable improvements in psychosocial well-being, however; seizure freedom is not key to improving the psychosocial life of patients who have undergone extratemporal lobe epilepsy surgery.
这项前瞻性临床研究的目的是检查因药物难治性癫痫而接受颞叶外切除术的一系列连续患者的短期和长期心理社会结局。
样本包括23例连续患者,所有患者均完成了一份问卷,该问卷特别评估了术后6个月和2年的心理社会结局。将短期和长期随访获得的结果与基线进行比较。此外,还探讨了无癫痫发作对心理社会结局的影响。
结果表明,无论癫痫发作状态如何,与术前状态相比,术后心理社会结局均得到改善。在长期随访中,社会和心理变量有显著改善(p<0.05)。与基线相比,长期药物副作用水平较高(p=0.003)。无癫痫发作的患者比术后有癫痫发作的患者表现出更好的心理社会结局,然而,只有“癫痫影响”量表在术后6个月显示出显著改善(p=0.02)。
这些结果提供了证据,表明手术在心理社会幸福感方面带来了明显改善,然而,无癫痫发作并非改善颞叶外癫痫手术患者心理社会生活的关键。