上皮-间质转化和衰老的失调：单一 Twist 蛋白的双重影响
Deregulating EMT and senescence: double impact by a single twist.
作者信息
Smit Marjon A, Peeper Daniel S
机构信息
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
出版信息
Cancer Cell. 2008 Jul 8;14(1):5-7. doi: 10.1016/j.ccr.2008.06.012.
PMID:18598938
Abstract
The acquisition of a fully malignant phenotype is limited by several barriers, including cellular senescence and the requirement to undergo an epithelial-mesenchymal transition (EMT). Deregulation of these processes is believed to occur by largely independent events. In this issue of Cancer Cell, Ansieau et al. (2008) challenge this view.
摘要
获得完全恶性表型受到多种障碍的限制，包括细胞衰老以及经历上皮-间质转化（EMT）的必要性。这些过程的失调被认为主要是由独立事件引起的。在本期《癌细胞》杂志中，安西奥等人（2008年）对这一观点提出了质疑。
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