Pecchi E, Dallaporta M, Jean A, Thirion S, Troadec J D
Centre de Recherche en Neurobiologie-Neurophysiologie de Marseille (CRN2M), UMR 6231 CNRS, Université Paul Cézanne and Université de la Méditerranée, Marseille, France.
J Neuroimmunol. 2008 Aug 13;199(1-2):104-14. doi: 10.1016/j.jneuroim.2008.05.012. Epub 2008 Jul 7.
Anorexia-cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia-cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.
恶病质综合征是在患有慢性炎症性疾病的个体中观察到的一种非常常见的症状。本研究旨在探讨诱导型微粒体前列腺素E合酶-1（mPGES-1）在这些病理状态下出现的食欲减退中可能发挥的作用。为此，我们使用了癌症诱导的厌食模型，并且在此报告，尽管在恶病质综合征期间大脑中的mPGES-1酶没有上调，但mPGES-1基因敲除小鼠对肿瘤诱导的厌食具有抗性并维持其体重。
