Drug Ther Bull. 2008 Jul;46(7):53-4. doi: 10.1136/dtb.2008.06.0015.
Each year in the UK, around 1 in 5,000 people develops Bell's palsy--idiopathic unilateral lower motor neurone facial weakness of rapid onset. Of those who are not treated, about 16% end up with permanent moderate to severe weakness, which can result in facial dysfunction and disfigurement, and psychological difficulties. There has been longstanding controversy about what, if any, treatment should be given, with potential alternatives including corticosteroids, antiviral drugs, acupuncture and physiotherapy. We last reviewed this condition in 2006, indicating that "published trials on the efficacy of drug treatments have been poor and no firm conclusions can be drawn about the benefit of any single drug", and "it is unclear what place, if any, acupuncture and physiotherapy have in the management of patients with Bell's palsy". Here we update our conclusions in the light of recently published evidence.
在英国,每年约每5000人中就有1人患上贝尔氏面瘫——一种特发性单侧下运动神经元性面部迅速出现的无力症状。在未经治疗的患者中,约16%最终会出现永久性的中度至重度面部无力,这可能导致面部功能障碍和毁容,以及心理问题。对于是否应进行治疗以及应采用何种治疗方法,长期以来一直存在争议,可能的替代治疗方法包括皮质类固醇、抗病毒药物、针灸和物理治疗。我们上次于2006年对这种疾病进行了综述,指出“关于药物治疗疗效的已发表试验质量较差,无法就任何一种药物的益处得出确凿结论”,并且“针灸和物理治疗在贝尔氏面瘫患者的治疗中是否有作用(若有,作用如何)尚不清楚”。在此,我们根据最近发表的证据更新我们的结论。