Krüppel样因子4在正常稳态、癌症和干细胞中的作用。
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.
作者信息
Evans Paul M, Liu Chunming
机构信息
Department of Biochemistry and Molecular Biology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555-1448, USA.
出版信息
Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):554-64. doi: 10.1111/j.1745-7270.2008.00439.x.
Abstract
Krüpel-like factor 4 (KLF4) is a zinc finger-type transcription factor expressed in a variety of tissues, including the epithelium of the intestine and the skin, and it plays an important role in differentiation and cell cycle arrest. Depending on the gene targeted, KLF4 can both activate and repress transcription. Moreover, in certain cellular contexts, KLF4 can function as a tumor suppressor or an oncogene. Finally, KLF4 is important in reprogramming differentiated fibroblasts into inducible pluripotent stem cells, which highly resemble embryonic stem cells. This review summarizes what is known about the diverse functions of KLF4 as well as their molecular mechanisms.
摘要
Krüppel样因子4（KLF4）是一种锌指型转录因子，在包括肠道和皮肤上皮在内的多种组织中表达，并且在细胞分化和细胞周期停滞中发挥重要作用。根据所靶向的基因不同，KLF4既能激活转录也能抑制转录。此外，在某些细胞环境中，KLF4可作为肿瘤抑制因子或癌基因发挥作用。最后，KLF4在将分化的成纤维细胞重编程为诱导多能干细胞的过程中起重要作用，这些诱导多能干细胞与胚胎干细胞高度相似。本综述总结了目前已知的KLF4的多种功能及其分子机制。
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