Kariya Shin, Cureoglu Sebahattin, Schachern Patricia A, Paparella Michael M, Nishizaki Kazunori
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, 55455, USA.
Auris Nasus Larynx. 2009 Apr;36(2):221-3. doi: 10.1016/j.anl.2008.05.008. Epub 2008 Jul 7.
We describe the histopathological temporal bone findings of metastatic rhabdomyosarcoma in the patient with hearing loss and facial nerve paralysis. A 45-year-old female was admitted to the hospital with a mass of the left tibia. Surgical operation was performed and the pathological diagnosis was alveolar rhabdomyosarcoma. She showed left facial palsy and bilateral hearing loss. She was pronounced dead because of respiratory arrest caused by multiple metastases including meningeal metastasis after 14 months of total clinical course. Histological examination of the temporal bone revealed that the VII and VIII cranial nerves were involved by tumor cells in the internal auditory canal, and that the organ of Corti was damaged. In addition, the membranous labyrinth showed labyrinthitis. No remarkable bony destruction was observed in the internal auditory canal. Histopathological examination revealed that hearing loss and facial nerve paralysis of the patient was due to temporal bone metastasis of rhabdomyosarcoma.
我们描述了一名患有听力损失和面神经麻痹的转移性横纹肌肉瘤患者的颞骨组织病理学检查结果。一名45岁女性因左胫骨肿物入院。进行了手术，病理诊断为肺泡状横纹肌肉瘤。她出现左侧面神经麻痹和双侧听力损失。在整个临床病程14个月后，她因包括脑膜转移在内的多处转移导致呼吸骤停而宣告死亡。颞骨组织学检查显示，内耳道内的肿瘤细胞累及第VII和第VIII颅神经，柯蒂氏器受损。此外，膜迷路显示为迷路炎。在内耳道未观察到明显的骨质破坏。组织病理学检查显示，该患者的听力损失和面神经麻痹是由横纹肌肉瘤的颞骨转移所致。
