Chen Xiaojun, Xiao Wei, Qu Xun, Zhou Shengyu
Department of Respiratory Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, PR China.
Cancer Invest. 2008 Aug;26(7):718-24. doi: 10.1080/07357900801935631.
The beneficial effects of unfractionated heparin and low molecular weight heparin on cancer progression have been reported. In the study, the effect of dalteparin on pulmonary adenocarcinoma A549 cell line was observed in vitro. Our experiments revealed that: (1) dalteparin can inhibit the cell viability dose-dependently and time-dependently; (2) dalteparin can arrest the A549 cells in G(1) phase and induce them to early apoptosis; (3) dalteparin exerts its effects through p21(WAF1) and p27(KIP1) proteins; and (4) the changes of p21(WAF1) and p27(KIP1) proteins caused by dalteparin occurred at posttranscriptional levels.
已有报道称普通肝素和低分子量肝素对癌症进展具有有益作用。在该研究中，体外观察了达肝素对肺腺癌A549细胞系的作用。我们的实验显示：（1）达肝素可剂量和时间依赖性地抑制细胞活力；（2）达肝素可使A549细胞停滞于G(1)期并诱导其早期凋亡；（3）达肝素通过p21(WAF1)和p27(KIP1)蛋白发挥作用；（4）达肝素引起的p21(WAF1)和p27(KIP1)蛋白变化发生在转录后水平。
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