Drewes Asbjørn M, Gratkowski Maciej, Sami Saber A K, Dimcevski Georg, Funch-Jensen Peter, Arendt-Nielsen Lars
Department of Medical Gastroenterology, Aalborg University Hospital, Aalborg DK-9000, Denmark.
World J Gastroenterol. 2008 Jul 7;14(25):4020-7. doi: 10.3748/wjg.14.4020.
To prove the hypothesis that patients with chronic pancreatitis would show increased theta activity during painful visceral stimulation.
Eight patients and 12 healthy controls underwent an experiment where the esophagus was electrically stimulated at the pain threshold using a nasal endoscope. The electroencephalogram (EEG) was recorded from 64 surface electrodes and "topographic matching pursuit" was used to extract the EEG information in the early brain activation after stimulation.
A major difference between controls and patients were seen in delta and theta bands, whereas there were only minor differences in other frequency bands. In the theta band, the patients showed higher activity than controls persisting throughout the 450 ms of analysis with synchronous brain activation between the channels. The main theta components oscillated with 4.4 Hz in the patients and 5.5 Hz in the controls. The energy in the delta (0.5-3.5 Hz) band was higher in the controls, whereas the patients only showed scattered activity in this band.
The differences in the theta band indicate that neuropathic pain mechanisms are involved in chronic pancreatitis. This has important implications for the understanding and treatment of pain in these patients, which should be directed against drugs with effects on neuropathic pain disorders.
验证慢性胰腺炎患者在疼痛性内脏刺激期间θ波活动会增加这一假说。
8例患者和12名健康对照者接受了一项实验，使用鼻内镜在疼痛阈值水平对食管进行电刺激。通过64个表面电极记录脑电图（EEG），并采用“地形匹配追踪”法提取刺激后早期脑激活中的EEG信息。
对照组和患者之间在δ波和θ波频段存在主要差异，而在其他频段仅有微小差异。在θ波频段，患者在整个450毫秒的分析过程中均表现出比对照组更高的活动，且各通道间存在同步脑激活。患者的主要θ波成分以4.4赫兹振荡，对照组为5.5赫兹。对照组在δ波（0.5 - 3.5赫兹）频段的能量更高，而患者在该频段仅表现出散在活动。
θ波频段的差异表明慢性胰腺炎涉及神经病理性疼痛机制。这对于理解和治疗这些患者的疼痛具有重要意义，治疗应针对对神经病理性疼痛障碍有效的药物。
