瑞典患者中，MHC II类反式激活因子基因的多态性与结直肠癌易感性无关。
Polymorphism in MHC class II transactivator gene is not associated with susceptibility to colorectal cancer in Swedish patients.
作者信息
Mumtaz Melad, Löfgren Sture, Hugander Anders, Dimberg Jan
机构信息
Department of Biotechnology, Al-Nahrain University, Baghdad, Iraq.
出版信息
Anticancer Res. 2008 May-Jun;28(3B):1789-91.
BACKGROUND
Reduced expression of major histocompatibility complex class II (MHC-II) genes in colorectal cancer (CRC) has been reported. MHC-II transactivator (CIITA), encoded by the MHC2TA gene, is considered to be the master regulator for MHC-II gene expression. A functional single nucleotide polymorphism (SNP) -168A-->G in the promoter region of the MHC2TA gene is suggested to have an influence on different autoimmune diseases.
PATIENTS AND METHODS
Our study was performed to evaluate the association between the -168A-->G MHC2TA gene variant in patients with CRC versus a control group. Using the TaqMan system, this SNP was screened in 248 CRC patients and 256 controls.
RESULTS
No significant difference in genotype distribution or in allelic frequencies was found between the two groups, nor any association with clinical characteristics.
CONCLUSION
The results of this study suggest that -168A-->G polymorphism of the MHC2TA gene is not associated with susceptibility to CRC.
背景
已有报道称结直肠癌（CRC）中主要组织相容性复合体II类（MHC-II）基因表达降低。由MHC2TA基因编码的MHC-II反式激活因子（CIITA）被认为是MHC-II基因表达的主要调节因子。MHC2TA基因启动子区域的功能性单核苷酸多态性（SNP）-168A→G被认为会影响不同的自身免疫性疾病。
患者与方法
我们开展本研究以评估CRC患者与对照组中MHC2TA基因-168A→G变异之间的关联。使用TaqMan系统，在248例CRC患者和256例对照中筛查该SNP。
结果
两组之间在基因型分布或等位基因频率上均未发现显著差异，也未发现与临床特征有任何关联。
结论
本研究结果表明，MHC2TA基因的-168A→G多态性与CRC易感性无关。
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