Zang Wei, Shen Yu-Juan, Cao Jian-Ping
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, MOH, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Feb 28;26(1):63-6.
Dendritic cells act as the major antigen presenting cells in the body and play a central role in intriguing the adaptive immune response. Protective immunity against schistosome and immuno-pathological response in host caused by eggs are both closely associated with Th2 response. Further understanding on immune mechanism will contribute to the development of vaccines against schistosome infection, as well as the relief of the pathological lesion in schistosomiasis. This article discusses the central role of dendritic cells in the mechanism of Th2 response induced by schistosome (including eggs).
树突状细胞是体内主要的抗原呈递细胞，在激发适应性免疫反应中起核心作用。针对血吸虫的保护性免疫以及虫卵在宿主体内引起的免疫病理反应均与Th2反应密切相关。对免疫机制的进一步了解将有助于开发抗血吸虫感染疫苗，以及缓解血吸虫病的病理损伤。本文讨论了树突状细胞在血吸虫（包括虫卵）诱导的Th2反应机制中的核心作用。
