甲状腺结节超声检查中微钙化表现对恶性肿瘤的预测价值

Predictive value for malignancy in the finding of microcalcifications on ultrasonography of thyroid nodules.

作者信息

Chammas Maria Cristina, de Araujo Filho Vergilius José F, Moysés Raquel A, Brescia Marília D G, Mulatti Grace C, Brandão Lenine G, Cerri Giovanni G, Ferraz Alberto R

机构信息

Department of Radiology, University of São Paulo Medical School, São Paulo, Brazil.

出版信息

Head Neck. 2008 Sep;30(9):1206-10. doi: 10.1002/hed.20858.

DOI:10.1002/hed.20858

PMID:18642291

Abstract

BACKGROUND

The aim of this study was to determine the predictive value for malignancy of microcalcifications determined by ultrasonography in thyroid nodules.

METHODS

One hundred seventy-seven nodules were prospectively studied by ultrasonography and compared with their fine-needle aspirative biopsy. The association between the presence and type of calcification and cytologic findings was verified through the chi-square test or likelihood ratio.

RESULTS

Thirty nodules showed calcification, of which 17 had fine calcifications, 3 had fine and gross calcifications, and 10 had only coarse calcification. Seven (41.18%) of 17 fine calcified nodules were malignant on cytology, 8 (47.06%) were benign, 1 (5.88%) was indeterminate, and 1 was suspect for malignancy. We found statistical significance between the presence of fine calcifications and malignancy (p = .001) and, in the 13 malignant nodule group, 8 (61.50%) had fine calcifications.

CONCLUSION

This study suggests that microcalcifications were highly specific for malignancy and were present in 61% of the malignant nodules.

摘要

背景

本研究的目的是确定超声检查所发现的甲状腺结节微钙化对恶性肿瘤的预测价值。

方法

前瞻性地对177个结节进行超声检查，并与细针穿刺活检结果进行比较。通过卡方检验或似然比验证钙化的存在及类型与细胞学检查结果之间的关联。

结果

30个结节显示有钙化，其中17个有微小钙化，3个有微小钙化和粗大钙化，10个只有粗大钙化。17个微小钙化结节中，7个（41.18%）细胞学检查为恶性，8个（47.06%）为良性，1个（5.88%）结果不确定，1个疑似恶性。我们发现微小钙化的存在与恶性肿瘤之间具有统计学意义（p = 0.001），在13个恶性结节组中，8个（61.50%）有微小钙化。