Hauser Jörg, Halfmann Helmut, Awakowicz Peter, Köller Manfred, Esenwein Stefan A
Klinik für Plastische Chirurgie, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum, Deutschland.
Biomed Tech (Berl). 2008 Aug;53(4):199-203. doi: 10.1515/BMT.2008.024.
The potential of plasma treatment in medicine is only slowly gaining acceptance. Inactivation of germs through exposure to UV radiation produced by plasma discharges and sterilization of medical implant devices and instruments is one possible application of this technique. In addition, due to the manifold possibilities of coating through plasma processes, quick sterilization-coating combinations of medical implant devices are possible. To analyze the effectiveness of this sterilization process on different material surfaces, three different alloys (X2CrNiMo18-15-3, Ti6Al7Nb and Ti6Al4V) and one thermoplastic material (ultra-high molecular weight polyethylene, UHMWPE), commonly used in medical implant devices, were examined in the presented study. After spraying Bacillus atrophaeus spores (10(6) CFU) on the surfaces of four different implant materials tested in this study (X2CrNiMo18-15-3, UHMWPE, Ti6Al7Nb and Ti6Al4V), it was demonstrated in each of four gas mixtures used (Ar, Ar:O2, Ar:H2 and Ar:N2) that due to the application of inductively coupled low-pressure plasma technique, plain medical implant materials can be sterilized rapidly, and can be protective and efficient.
等离子体处理在医学领域的潜力正逐渐被认可。通过暴露于等离子体放电产生的紫外线辐射来灭活细菌,以及对医疗植入设备和器械进行消毒,是该技术的一种可能应用。此外,由于等离子体工艺具有多种涂层可能性,医疗植入设备的快速消毒 - 涂层组合成为可能。为了分析这种消毒过程在不同材料表面的有效性,本研究对三种不同的合金(X2CrNiMo18 - 15 - 3、Ti6Al7Nb和Ti6Al4V)以及一种常用于医疗植入设备的热塑性材料(超高分子量聚乙烯,UHMWPE)进行了检测。在本研究测试的四种不同植入材料(X2CrNiMo18 - 15 - 3、UHMWPE、Ti6Al7Nb和Ti6Al4V)表面喷洒萎缩芽孢杆菌孢子(10(6) CFU)后,在所使用的四种气体混合物(Ar、Ar:O2、Ar:H2和Ar:N2)中的每一种中都证明,由于应用了电感耦合低压等离子体技术,普通医疗植入材料能够快速消毒,并且具有防护性和高效性。