Oda Yoichi
Laboratory of Brain Function and Structure, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Jun;28(3):127-30.
Hindbrain reticulospinal (RS) neurons in goldfish and zebrafish consist of seven clusters spaced periodically along the rostrocaudal axis. Morphologically similar RS neurons, homologs, are arranged in adjacent segments. Electrophysiological examination in goldfish suggests that paired, large M-cells, in the fourth segment (r4) and their homologs, MiD 2 cm in r5 and MiD 3 cm in r6, receive auditory inputs similarly but show different firing pattern in response to depolarization. In addition, there is inhibitory connection from M-cell to its homologs but not in the reverse direction. Calcium imaging of these neurons during escape behavior in larval zebrafish reveals that the M-cell and its homologs fire in a complementary fashion. Thus, the segmentally homologous RS neurons may work as a functional unit to initiate and control escape behavior.
金鱼和斑马鱼的后脑网状脊髓（RS）神经元由沿头尾轴周期性排列的七个簇组成。形态学上相似的RS神经元，即同源物，排列在相邻节段中。对金鱼的电生理检查表明，位于第四节段（r4）的成对大M细胞及其在r5中的同源物MiD 2 cm和在r6中的同源物MiD 3 cm，接收相似的听觉输入，但在去极化时表现出不同的放电模式。此外，存在从M细胞到其同源物的抑制性连接，但反之则不存在。在斑马鱼幼体逃避行为期间对这些神经元进行钙成像显示，M细胞及其同源物以互补方式放电。因此，节段性同源RS神经元可能作为一个功能单元来启动和控制逃避行为。
