Burkhart Deborah L, Sage Julien
Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA.
Nat Rev Cancer. 2008 Sep;8(9):671-82. doi: 10.1038/nrc2399.
The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified for the RB protein. Data from human tumours and studies from mouse models indicate that loss of RB function contributes to both cancer initiation and progression. However, we still do not know the identity of the cell types in which RB normally prevents cancer initiation in vivo, and the specific functions of RB that suppress distinct aspects of the tumorigenic process are poorly understood.
视网膜母细胞瘤（RB）肿瘤抑制基因在多种儿科和成人癌症中功能失活，并且已确定RB蛋白具有大量细胞功能和相互作用蛋白。来自人类肿瘤的数据和小鼠模型研究表明，RB功能丧失促进癌症的起始和进展。然而，我们仍然不知道RB在体内正常情况下预防癌症起始的细胞类型，以及RB抑制肿瘤发生过程不同方面的具体功能也知之甚少。
