Couppis Maria H, Kennedy Craig H, Stanwood Gregg D
Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee 37232, USA.
Synapse. 2008 Oct;62(10):715-24. doi: 10.1002/syn.20545.
The neurotransmitters DA and serotonin are known to be important modulators of aggression, but endogenous differences in these systems between aggressive and nonaggressive animals are poorly understood. To examine this issue, the mesocorticolimbic DA and serotonin systems of two mouse strains that differ in aggressive behavior, BALB/cJ and A/J, were analyzed using high performance liquid chromatography and quantitative receptor autoradiography. Significant differences in both serotonergic and dopaminergic systems were found between aggressive and nonaggressive mice. The nonaggressive A/J mice exhibited higher DA utilization in the nucleus accumbens and prefrontal cortex, higher D1 receptor expression in the rostral pole of the accumbens, and lower D2 receptor expression throughout the accumbens, as compared with aggressive BALB/cJ mice. Although correlative in nature, these data suggest that differences in mesocorticolimbic DA and serotonin systems may contribute to endogenous differences in aggression.
已知神经递质多巴胺（DA）和5-羟色胺是攻击行为的重要调节因子，但对于具有攻击性和非攻击性的动物之间，这些系统的内源性差异却知之甚少。为了研究这个问题，我们使用高效液相色谱法和定量受体放射自显影技术，分析了两种在攻击行为上存在差异的小鼠品系——BALB/cJ和A/J——的中脑边缘多巴胺和5-羟色胺系统。结果发现，具有攻击性和非攻击性的小鼠在5-羟色胺能和多巴胺能系统方面均存在显著差异。与具有攻击性的BALB/cJ小鼠相比，非攻击性的A/J小鼠在伏隔核和前额叶皮质中的多巴胺利用率更高，在伏隔核嘴端的D1受体表达更高，而在整个伏隔核中的D2受体表达更低。尽管这些数据本质上具有相关性，但它们表明中脑边缘多巴胺和5-羟色胺系统的差异可能导致攻击行为的内源性差异。
