Tasciotti Ennio, Liu Xuewu, Bhavane Rohan, Plant Kevin, Leonard Ashley D, Price B Katherine, Cheng Mark Ming-Cheng, Decuzzi Paolo, Tour James M, Robertson Fredika, Ferrari Mauro
Nat Nanotechnol. 2008 Mar;3(3):151-7. doi: 10.1038/nnano.2008.34. Epub 2008 Mar 2.
Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion.
许多纳米级颗粒系统正被开发用作血管内载体，以增加输送到靶点的治疗剂水平，并使副作用最小化。这些载体的表面通常用生物识别分子进行功能化修饰，以实现特异性靶向递送。然而，体内存在一系列生物屏障，会阻止这些载体以足够高的治疗浓度定位到靶点。在此，我们展示了一种多阶段递送系统，该系统能够携带、随时间释放并将两种类型的纳米颗粒递送至原代内皮细胞。该多阶段递送系统基于具有形状、尺寸和孔隙可控的可生物降解且生物相容的介孔硅颗粒。预计该系统的应用将开辟新途径，以避开生物屏障，并以时间可控的方式一次向靶点递送不止一种治疗剂。
