导水管周围灰质中促炎趋化因子RANTES/CCL5水平升高会导致大鼠痛觉过敏。
Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats.
作者信息
Benamar Khalid, Geller Ellen B, Adler Martin W
机构信息
Center for Substance Abuse Research (CSAR), Temple University School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140, USA.
出版信息
Eur J Pharmacol. 2008 Sep 11;592(1-3):93-5. doi: 10.1016/j.ejphar.2008.07.009. Epub 2008 Jul 11.
The present data provide the first in vivo evidence that the proinflammatory chemokine, Regulated on Activation Normal T cell Expressed and Secreted (RANTES/CCL5) microinjected directly into the periaqueductal grey in rats, a brain region critical to the processing of pain signals, and a primary site of action of many analgesic compounds, induced hyperalgesia. Pretreatment with antibodies against RANTES/CCL5 prevented the hyperalgesic response, indicating that RANTES/CCL5 is able to interfere with the control of hyperalgesia at the level of the periaqueductal grey and suggesting that chemokine blockers could have analgesic properties.
目前的数据首次提供了体内证据，表明将促炎趋化因子“正常T细胞激活时表达和分泌的调控因子”（RANTES/CCL5）直接微量注射到大鼠中脑导水管周围灰质（对疼痛信号处理至关重要的脑区，也是许多镇痛化合物的主要作用部位）会诱发痛觉过敏。用抗RANTES/CCL5抗体进行预处理可防止痛觉过敏反应，这表明RANTES/CCL5能够在中脑导水管周围灰质水平干扰痛觉过敏的控制，并提示趋化因子阻滞剂可能具有镇痛特性。
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