接受利妥昔单抗治疗的心脏移植患者中，爱泼斯坦-巴尔病毒聚合酶链反应阴性的IV期移植后淋巴增殖性疾病
Epstein-Barr virus polymerase chain reaction-negative stage IV post-transplant lymphoproliferative disorder in a heart transplant patient treated with rituximab.
作者信息
Garceau Patrick, Couture Christian, Cantin Bernard, Bernier Vincent, Sénéchal Mario
机构信息
Institut de Cardiologie de Québec, Hôpital Laval, Sainte-Foy, Québec, Canada.
出版信息
J Heart Lung Transplant. 2008 Aug;27(8):928-31. doi: 10.1016/j.healun.2008.05.020. Epub 2008 Jul 3.
PMID:18656811
Abstract
Post-transplant lymphoproliferative disorder (PTLD) is often associated with Epstein-Barr virus (EBV). However, in this report, we describe a heart transplant recipient with pathologically proven EBV-positive PTLD with undetectable virus by polymerase chain reaction. The patient had remission after anti-CD20 antibody treatment early after transplantation.
摘要
移植后淋巴细胞增生性疾病（PTLD）常与 Epstein-Barr 病毒（EBV）相关。然而，在本报告中，我们描述了一名心脏移植受者，其经病理证实为 EBV 阳性的 PTLD，但通过聚合酶链反应检测不到病毒。该患者在移植后早期接受抗 CD20 抗体治疗后病情缓解。
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