组胺诱导的瘙痒及其与疼痛的关系。
Histamine-induced itch and its relationship with pain.
作者信息
Shim Won-Sik, Oh Uhtaek
机构信息
National Research Laboratory of Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy,Seoul National University, Seoul, 151-742, Korea.
出版信息
Mol Pain. 2008 Jul 31;4:29. doi: 10.1186/1744-8069-4-29.
Itch is one of the major complications of skin diseases. Although there are various substances that induce itch or pruritus, it is evident that histamine is the best known endogenous agent that evokes itch. Even though histamine-induced itch has been studied for some time, the underlying mechanism of itch is just beginning to emerge. Although various downstream signaling pathways of histamine receptors have been revealed, more studies are required to determine the cause of histamine-induced itch. It appears that itch and pain involve different neuronal pathways. Pain generally inhibits itch, which indicates an inter-communication between the two. Complex interactions between itch and pain may be expected based on reports on disease states and opioids. In this review, we discuss the molecular mechanism and the pharmacological aspects of histamine-induced itch. Especially, the underlying mechanism of TRPV1 (an anti-pruritus target) has been determined to some extent.
瘙痒是皮肤病的主要并发症之一。尽管有多种物质可诱发瘙痒，但很明显组胺是最广为人知的引发瘙痒的内源性介质。尽管组胺诱导的瘙痒已经研究了一段时间，但其潜在机制才刚刚开始显现。虽然组胺受体的各种下游信号通路已被揭示，但仍需要更多研究来确定组胺诱导瘙痒的原因。瘙痒和疼痛似乎涉及不同的神经元通路。疼痛通常会抑制瘙痒，这表明两者之间存在相互联系。基于疾病状态和阿片类药物的报道，瘙痒和疼痛之间可能存在复杂的相互作用。在本综述中，我们讨论了组胺诱导瘙痒的分子机制和药理学方面。特别是，TRPV1（一种抗瘙痒靶点）的潜在机制已在一定程度上得到确定。
Zotero 插件