硅胶凝胶对烧伤瘢痕的影响。
Effects of silicone gel on burn scars.
作者信息
Momeni Mahnoush, Hafezi Farhad, Rahbar Hossein, Karimi Hamid
机构信息
Motahary Burn and Reconstructive Centre, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Burns. 2009 Feb;35(1):70-4. doi: 10.1016/j.burns.2008.04.011. Epub 2008 Jul 30.
AIM
To study the efficacy of silicone gel applied to hypertrophic burn scars, in reducing scar interference with normal function and improving cosmesis.
METHODS
A randomised, double-blind, placebo-controlled trial involving 38 people with hypertrophic burn scars. Each scar was divided into two segments; silicone gel sheet was applied randomly to one of the two and placebo to the other. Participants were seen again after 1 and 4 months. Their data and wound characteristics were collected using the Vancouver scar scale.
RESULTS
The median age of participants was 22 years (1.5-60 years) and 16 were male; 4 did not attend follow-up and were excluded from the study. There were no significant differences in baseline characteristics. Although after 1 month all scar scale measures were lower in treated areas, only the vascularity scale was significantly different between the two areas. After 4 months, all scale measures were significantly lower in the silicone gel group than in the control group, except for the pain score.
CONCLUSION
Silicone gel is an effective treatment for hypertrophic burn scars.
目的
研究硅胶凝胶应用于烧伤增生性瘢痕，在减少瘢痕对正常功能的干扰及改善美容效果方面的疗效。
方法
一项随机、双盲、安慰剂对照试验，纳入38例烧伤增生性瘢痕患者。将每个瘢痕分为两段；随机将硅胶凝胶片应用于其中一段，另一段应用安慰剂。1个月和4个月后再次对参与者进行观察。使用温哥华瘢痕量表收集他们的数据和伤口特征。
结果
参与者的中位年龄为22岁（1.5 - 60岁），男性16例；4例未参加随访，被排除在研究之外。基线特征无显著差异。虽然1个月后治疗区域的所有瘢痕量表测量值均较低，但两个区域之间仅血管量表有显著差异。4个月后，除疼痛评分外，硅胶凝胶组的所有量表测量值均显著低于对照组。
结论
硅胶凝胶是治疗烧伤增生性瘢痕的有效方法。
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