Rehm T, Benga L, Danilowicz E, Drungowski M, Hoeltig D, Kahlisch D, Oehlmann W, Probst I, Gerlach G F
Zentrum für Infektionsmedizin, Institut für Mikrobiologie der Stiftung Tierärztliche Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 2008 Jul;115(7):260-4.
Here we present the work of the multidisciplinary consortium IRAS (Development of Genetic Markers for Immune Defence and Resistance in the Porcine Respiratory Tract) which includes different commercial and research institutions and was formed as a response to the call "Functional Genome Analysis in the Animal Organism (FUGATO)" by the German Ministry of Education and Research. IRAS started work in the fall of 2005 and--using the experimental infection of pigs with Actinobacillus pleuropneumoniae as model pathogen--aims at i) characterizing the course of infection by clinical as well as advanced laboratory tools (phenotypic-genetic approach) and ii) defining the diversity and distribution of allels known to be associated with immune defence in mouse and man (homolog-genetic approach). The intention is to identify genetic markers for increased resistance to infection thereby providing additional tools for the estimation of breeding values to the pig industry.
在此，我们展示了多学科联盟IRAS（猪呼吸道免疫防御和抗性基因标记的开发）的工作，该联盟包括不同的商业机构和研究机构，是为响应德国教育和研究部发起的“动物机体功能基因组分析（FUGATO）”号召而组建的。IRAS于2005年秋季开始工作，以猪感染胸膜肺炎放线杆菌作为模式病原体进行实验感染，旨在：i）通过临床以及先进的实验室工具（表型-遗传方法）来描述感染过程；ii）确定已知与小鼠和人类免疫防御相关的等位基因的多样性和分布（同源-遗传方法）。其目的是识别出增强抗感染能力的基因标记，从而为养猪业提供用于估计育种值的额外工具。
