Heider Luke C, Meiring Richard W, Hoet Armando E, Gebreyes Wondwossen A, Funk Julie A, Wittum Thomas E
Department of Veterinary Preventative Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
J Am Vet Med Assoc. 2008 Aug 1;233(3):466-9. doi: 10.2460/javma.233.3.466.
To estimate the efficacy of a commercially available Salmonella enterica subunit vaccine on the subclinical shedding of S enterica in dairy cattle.
Randomized, controlled trial.
175 mature cows on 2 dairy farms with a history of S enterica infection.
25% of the mature cows from each herd were systematically randomized to receive an S enterica subunit vaccine following label guidelines. The remaining 75% of cows in each herd served as nonvaccinated controls. Fecal samples were collected from all cows at the time of initial vaccination (day 0), booster vaccination (day 14), 2 weeks following the booster vaccination (day 28), and 10 weeks following the start of the trial (day 70). All samples were processed on the day of collection and cultured for S enterica.
651 fecal samples were obtained over the entire study period. Salmonella enterica was recovered from 46 (7.1%) of the samples. Shedding of S enterica was similar for vaccinated and nonvaccinated control cows on each of the collection dates.
The study revealed no evidence that extralabel vaccination with a commercial subunit S enterica vaccine reduced shedding of S enterica in subclinically infected dairy cows in these herds.
评估一种市售肠炎沙门氏菌亚单位疫苗对奶牛亚临床状态下肠炎沙门氏菌排菌情况的效果。
随机对照试验。
来自2个有肠炎沙门氏菌感染病史的奶牛场的175头成年母牛。
按照标签说明，将每个牛群中25%的成年母牛系统地随机分配接受肠炎沙门氏菌亚单位疫苗。每个牛群中其余75%的母牛作为未接种疫苗的对照。在初次接种疫苗时（第0天）、加强接种疫苗时（第14天）、加强接种疫苗后2周（第28天）以及试验开始后10周（第70天），从所有母牛采集粪便样本。所有样本在采集当天进行处理，并培养肠炎沙门氏菌。
在整个研究期间共获得651份粪便样本。从46份（7.1%）样本中分离出肠炎沙门氏菌。在每个采集日期，接种疫苗的母牛和未接种疫苗的对照母牛的肠炎沙门氏菌排菌情况相似。
该研究未发现证据表明，在这些牛群中，超说明书使用市售亚单位肠炎沙门氏菌疫苗可减少亚临床感染奶牛的肠炎沙门氏菌排菌。
