盐酸他克林在人血清和尿液中的代谢产物与肝微粒体体外代谢产物的色谱特征比较。
Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes.
作者信息
Truman C A, Ford J M, Roberts C J
机构信息
Department of Medicine, Bristol Royal Infirmary, U.K.
出版信息
Biochem Pharmacol. 1991 Jul 25;42(4):956-9. doi: 10.1016/0006-2952(91)90061-9.
PMID:1867652
Abstract
There may be as many as five metabolites of THA in man, four corresponding to products in the rat. The study provides some evidence that one of major metabolites is 1-hydroxy-THA but lends no support to the putative oxidative deamination pathway.
摘要
人体内THA的代谢产物可能多达五种，其中四种与大鼠体内的产物相对应。该研究提供了一些证据，表明主要代谢产物之一是1-羟基-THA，但并未支持假定的氧化脱氨途径。
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