Cui Yingjun, Li Qingzhang
Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, China.
Sci China C Life Sci. 2008 Aug;51(8):711-7. doi: 10.1007/s11427-008-0092-y. Epub 2008 Aug 3.
To investigate the regulation of estrogen, progesterone and prolactin stimulating the development of mammary gland, the Kunming mice were used as experimental animals in this study. Through the experiment in vitro, the effect of mammogenic hormones were systematically investigated on expression of FGF7 and FGF10 and their receptor in different periods. The results are as follows: in mammary glands of mice, 17 beta-estradiol increased the expression of FGF7; progesterone did not affect the expression of FGF7; prolactin up-regulated the expression of FGF7 significantly in pregnancy and lactation. 17 beta-estradiol increased the expression of FGF10; progesterone and prolactin reduced the expression of FGF10 significantly in virgin; prolactin significantly increased the expression of FGF10 in pregnancy. When 17 beta-estradiol in the body was in relatively high proportion, it would lower the expression of KGFR; while 17 beta-estradiol in the body was in relatively low proportion, it would increase the expression of KGFR. Low concentration of progesterone increased the expression of KGFR and high progesterone did not affect the expression of KGFR. Prolactin increased the expression of KGFR significantly in pregnancy and lactation.
为研究雌激素、孕激素和催乳素对乳腺发育的调控作用，本研究选用昆明小鼠作为实验动物。通过体外实验，系统研究了乳腺生成激素在不同时期对FGF7和FGF10及其受体表达的影响。结果如下：在小鼠乳腺中，17β-雌二醇增加FGF7的表达；孕激素不影响FGF7的表达；催乳素在妊娠和哺乳期显著上调FGF7的表达。17β-雌二醇增加FGF10的表达；孕激素和催乳素在未孕时显著降低FGF10的表达；催乳素在妊娠时显著增加FGF10的表达。当体内17β-雌二醇比例相对较高时，会降低KGFR的表达；而当体内17β-雌二醇比例相对较低时，会增加KGFR的表达。低浓度孕激素增加KGFR的表达，高浓度孕激素不影响KGFR的表达。催乳素在妊娠和哺乳期显著增加KGFR的表达。
